OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 139 768.31 110.78 47,698,022
Mutual Fund 200 318.18 49.85 21,462,810
Insider 4 6.45 0.87 372,793

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 93 111.12 16.08 6,925,337
Sellers 61 -64.22 9.30 -4,005,809
Net -- 46.90 6.78 2,919,528

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 768.31 110.78 47,698,022
Top 10 Inst. 547.84 78.88 33,964,151
Top 20 Inst. 689.83 99.32 42,764,677
Top 50 Inst. 752.86 108.52 46,726,239

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 31 59.69 8.68 3,735,642
Aggressive Growth 1 0.02 -- 1,517
Core Growth 23 32.28 4.67 2,011,859
Growth 7 27.40 4.00 1,722,266
Income 4 37.45 5.39 2,322,107
Income Value 2 36.38 5.24 2,255,233
Yield 2 1.07 0.16 66,874
Index 19 117.32 16.90 7,275,575
Other 48 433.98 62.52 26,920,673
Broker Dealer 10 4.07 0.59 252,168
GARP 14 169.23 24.38 10,497,611
Hedge Fund 19 64.26 9.27 3,993,406
Sector Specific 2 49.63 7.15 3,076,962
Specialty 2 0.18 0.03 11,485
VC/Private Equi 1 146.61 21.11 9,089,041
Value 16 103.37 14.89 6,413,156
Core Value 15 101.55 14.63 6,300,458
Deep Value 1 1.82 0.26 112,698

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 9,089,041 21.11 504,913 6/30/18
Wellington Management Company, LLP 5,592,390 12.99 -195,064 6/30/18
T. Rowe Price Associates, Inc. 3,447,508 8.01 576,733 6/30/18
OppenheimerFunds, Inc. 2,961,194 6.88 456,269 6/30/18
BlackRock Institutional Trust Company, N.A. 2,613,100 6.07 1,656,106 6/30/18
Fidelity Management & Research Company 2,477,963 5.76 4,013 6/30/18
Franklin Advisers, Inc. 2,163,825 5.03 55,646 6/30/18
Redmile Group, LLC 2,029,347 4.71 -252,921 6/30/18
State Street Global Advisors (US) 1,925,184 4.47 232,206 6/30/18
The Vanguard Group, Inc. 1,664,599 3.87 146,899 6/30/18
Jennison Associates LLC 1,593,857 3.70 26,236 6/30/18
Citadel LLC 1,453,077 3.37 290,524 6/30/18
Fidelity Institutional Asset Management 1,282,633 2.98 286,000 6/30/18
Janus Henderson Investors 1,184,530 2.75 -22,438 6/30/18
Polar Capital LLP 1,047,615 2.43 18,490 6/30/18
AXA Investment Managers UK Ltd. 612,939 1.42 104,307 6/30/18
Alyeska Investment Group, L.P. 459,102 1.07 -27,927 6/30/18
Ghost Tree Capital, LLC 400,000 0.93 150,000 6/30/18
Northern Trust Investments, Inc. 387,197 0.90 309,291 6/30/18
APG Asset Management 379,576 0.88 379,576 3/31/18
Geode Capital Management, L.L.C. 325,312 0.76 123,879 6/30/18
King (Rachel K) 317,802 0.74 -- 3/23/18
Baker Bros. Advisors LP 291,214 0.68 -272,098 6/30/18
RA Capital Management, LLC 253,547 0.59 -- 6/30/18
Invus Public Equities Advisors, LLC 250,000 0.58 -75,000 6/30/18
Sphera Funds Management Ltd. 239,933 0.56 89,933 6/30/18
Point72 Asset Management, L.P. 180,000 0.42 52,965 6/30/18
Thackray (Helen M) 148,615 0.35 -- 3/23/18
Schonfeld Strategic Advisors LLC 140,000 0.33 -99,575 6/30/18
Nuveen LLC 138,975 0.32 138,975 6/30/18
Millennium Management LLC 131,231 0.30 -105,403 6/30/18
Hudson Bay Capital Management LP 120,000 0.28 20,000 6/30/18
Dimensional Fund Advisors, L.P. 117,351 0.27 117,351 8/31/18
BlackRock Investment Management, LLC 112,698 0.26 108,247 6/30/18
Moore Capital Management, LP 100,000 0.23 -22,500 6/30/18
Deutsche Asset Management Americas 95,566 0.22 48,287 6/30/18
K2 Advisors L.L.C. 95,320 0.22 3,360 8/31/18
BNY Mellon Asset Management 91,408 0.21 60,490 6/30/18
Magnani (John L) 80,638 0.19 -25,000 10/18/18
Asset Management One Co., Ltd. 80,097 0.19 80,097 7/31/17
GAM Capital Management (Switzerland) AG 77,900 0.18 -- 6/30/18
Charles Schwab Investment Management, Inc. 74,022 0.17 74,022 6/30/18
Morgan Stanley & Co. LLC 72,121 0.17 63,836 6/30/18
TD Asset Management Inc. 69,172 0.16 12,700 6/30/18
Morgan Stanley Investment Management Inc. (US) 67,340 0.16 21,150 8/31/18
Alps Advisors, Inc. 61,659 0.14 15,605 6/30/18
Citi Investment Research (US) 59,414 0.14 -6,965 6/30/18
Schweizerische Nationalbank 59,200 0.14 59,200 6/30/18
GLG Partners LP 56,666 0.13 56,666 6/30/18
BlackRock Financial Management, Inc. 54,361 0.13 54,361 6/30/18

* Insider values reflect direct beneficial ownership.

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