United States securities and exchange commission logo March 10, 2022 Harout Semerjian Chief Executive Officer GlycoMimetics, Inc. 9708 Medical Center Drive Rockville, Maryland 20850 Re: GlycoMimetics, Inc. Registration Statement on Form S-3 Filed March 4, 2022 File No. 333-263297 Dear Mr. Semerjian: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Alan Campbell at 202-551-4224 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Brian Leaf