April 20, 2022




Alan Campbell 

Securities and Exchange Commission 

Division of Corporation Finance 

100 F Street, N.E. 

Washington, DC 20549


Re: GlycoMimetics, Inc. 
  Registration Statement on Form S-3; File No. 333-263297


  Acceleration Request 
  Requested Date: Friday, April 22, 2022 
  Requested Time: 4:00 p.m. Eastern Time


Dear Mr. Campbell:


In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the “Registrant”) hereby requests that the Securities and Exchange Commission (the “Commission”) take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-263297) (the “Registration Statement”) to become effective on Friday, April 22, 2022, at 4:00 p.m. Eastern Time, or as soon thereafter as is practicable, or at such later time as the Registrant may orally request via telephone call to the staff (the “Staff”).


Once the Registration Statement has been declared effective, please orally confirm that event with Katie Kazem of Cooley LLP, counsel to the Registrant, at (703) 456-8043, or in her absence, Brian Leaf at (703) 456-8053.


  Very truly yours,


  By: /s/ Brian M. Hahn
    Brian M. Hahn
    Chief Financial Officer