May 23, 2019

Rachel K. King
Chief Executive Officer
Glycomimetics, Inc.
9708 Medical Center Drive
Rockville, MD 20850

       Re: Glycomimetics Inc.
           Registration Statement on Form S-3
           Filed May 17, 2019
           File No. 333-231577

Dear Ms. King:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Christine Westbrook at 202-551-5019 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Healthcare & Insurance
cc:    Brian F. Leaf, Esq.