OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 127 727.09 105.47 44,814,314
Mutual Fund 109 289.52 39.78 16,903,322
Insider 4 7.06 0.94 397,793

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 78 245.22 35.57 15,112,782
Sellers 63 -62.12 8.97 -3,813,533
Net -- 183.09 26.60 11,299,249

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 727.09 105.47 44,814,314
Top 10 Inst. 509.46 73.87 31,389,978
Top 20 Inst. 636.01 92.22 39,187,320
Top 50 Inst. 705.00 102.24 43,445,254

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 29 64.10 9.41 3,997,060
Aggressive Growth 3 0.46 0.07 28,305
Core Growth 19 27.63 4.06 1,725,932
Growth 7 36.01 5.28 2,242,823
Income 4 35.57 5.16 2,190,870
Income Value 2 34.72 5.03 2,139,097
Yield 2 0.85 0.12 51,773
Index 11 74.73 10.83 4,603,426
Other 50 424.86 61.59 26,169,567
Broker Dealer 10 6.62 0.96 407,726
GARP 14 151.30 21.93 9,317,411
Hedge Fund 22 73.76 10.69 4,541,909
Sector Specific 2 53.74 7.79 3,311,393
Specialty 1 0.11 0.02 7,000
VC/Private Equi 1 139.32 20.20 8,584,128
Value 12 105.82 15.32 6,508,816
Core Value 10 105.73 15.30 6,503,207
Deep Value 2 0.08 0.01 5,609

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 8,584,128 20.20 -- 3/31/18
Wellington Management Company, LLP 5,787,454 13.62 2,209,032 3/31/18
T. Rowe Price Associates, Inc. 2,870,775 6.76 1,605,815 3/31/18
OppenheimerFunds, Inc. 2,504,925 5.90 2,504,925 3/31/18
Fidelity Management & Research Company 2,473,950 5.82 859,733 3/31/18
Redmile Group, LLC 2,282,268 5.37 351,600 3/31/18
Franklin Advisers, Inc. 2,108,179 4.96 178,800 3/31/18
State Street Global Advisors (US) 1,692,978 3.98 1,659,270 3/31/18
Jennison Associates LLC 1,567,621 3.69 -20,225 3/31/18
The Vanguard Group, Inc. 1,517,700 3.57 484,864 3/31/18
Janus Henderson Investors 1,206,968 2.84 229,209 3/31/18
Citadel LLC 1,162,553 2.74 749,434 3/31/18
Polar Capital LLP 1,029,125 2.42 349,789 3/31/18
Fidelity Institutional Asset Management 996,633 2.35 -227,833 3/31/18
BlackRock Institutional Trust Company, N.A. 956,994 2.25 -26,985 3/31/18
Baker Bros. Advisors LP 563,312 1.33 -- 3/31/18
Columbus Circle Investors 561,096 1.32 317,932 3/31/18
AXA Investment Managers UK Ltd. 508,632 1.20 -2,342 3/31/18
Alyeska Investment Group, L.P. 487,029 1.15 324,227 3/31/18
Invus Public Equities Advisors, LLC 325,000 0.76 75,000 3/31/18
King (Rachel K) 317,802 0.75 -- 3/23/18
RA Capital Management, LLC 253,547 0.60 253,547 3/31/18
Ghost Tree Capital, LLC 250,000 0.59 250,000 3/31/18
Farallon Capital Management, L.L.C. 250,000 0.59 250,000 3/31/18
Schonfeld Strategic Advisors LLC 239,575 0.56 -210,425 3/31/18
Millennium Management LLC 236,634 0.56 223,461 3/31/18
BlackRock Investment Management (UK) Ltd. 223,275 0.53 223,275 3/31/18
Geode Capital Management, L.L.C. 201,433 0.47 44,481 3/31/18
Goldman Sachs & Company, Inc. 169,499 0.40 56,333 3/31/18
Sphera Funds Management Ltd. 150,000 0.35 -175,000 3/31/18
Thackray (Helen M) 148,615 0.35 -- 3/23/18
Monashee Investment Management, LLC 140,000 0.33 140,000 3/31/18
Point72 Asset Management, L.P. 127,035 0.30 127,035 3/31/18
UBS Financial Services, Inc. 125,355 0.30 125,055 3/31/18
Moore Capital Management, LP 122,500 0.29 122,500 3/31/18
Invesco PowerShares Capital Management LLC 117,846 0.28 -61,686 3/31/18
BlueCrest Capital Management LLP 108,932 0.26 108,932 3/31/18
Magnani (John L) 105,638 0.25 1,491 5/23/18
Balyasny Asset Management LP 101,986 0.24 101,986 3/31/18
Hudson Bay Capital Management LP 100,000 0.24 -40,000 3/31/18
Credit Suisse Securities (USA) LLC 82,551 0.19 70,626 3/31/18
Asset Management One Co., Ltd. 80,097 0.19 80,097 7/31/17
Northern Trust Investments, Inc. 77,906 0.18 13,018 3/31/18
GAM Capital Management (Switzerland) AG 77,900 0.18 77,900 3/31/18
GAM Investment Management (Switzerland) AG 76,149 0.18 46,843 4/30/18
Medical Strategy GmbH 76,022 0.18 -4,347 3/31/18
Macquarie Investment Management 75,749 0.18 75,749 3/31/18
Peregrine Capital Management, LLC 75,749 0.18 75,749 3/31/18
Allianz Global Investors GmbH 73,433 0.17 73,433 3/31/18
K2 Advisors L.L.C. 72,706 0.17 6,264 4/30/18

* Insider values reflect direct beneficial ownership.

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