OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 91 426.23 89.82 30,841,690
Mutual Fund 69 82.68 18.62 6,393,117
Insider 4 2.38 0.75 259,127

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 39 30.17 6.29 2,161,067
Sellers 64 -45.62 9.95 -3,415,131
Net -- -15.45 3.66 -1,254,064

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 426.23 89.82 30,841,690
Top 10 Inst. 337.99 70.36 24,159,648
Top 20 Inst. 391.52 82.07 28,180,221
Top 50 Inst. 423.56 89.11 30,597,432

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 21 45.28 9.52 3,267,729
Aggressive Growth 2 1.91 0.40 136,824
Core Growth 15 18.28 3.89 1,336,171
Growth 4 25.09 5.23 1,794,734
Income 2 26.34 5.48 1,882,788
Income Value 2 26.34 5.48 1,882,788
Index 7 24.89 5.18 1,779,140
Momentum 1 0.92 0.44 150,000
Other 29 263.97 55.04 18,898,977
Broker Dealer 5 2.10 0.44 149,921
GARP 8 37.91 7.96 2,733,871
Hedge Fund 12 82.02 17.09 5,869,381
Sector Specific 2 21.71 4.52 1,551,676
Specialty 1 0.14 0.03 10,000
VC/Private Equi 1 120.09 25.00 8,584,128
Value 10 52.70 10.98 3,768,614
Core Value 7 52.63 10.96 3,763,143
Deep Value 3 0.07 0.02 5,471

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 8,584,128 25.00 -- 9/30/17
Wellington Management Company, LLP 3,494,870 10.18 44,332 9/30/17
BVF Partners L.P. 3,229,856 9.41 259,674 9/30/17
Franklin Advisers, Inc. 1,859,079 5.41 -- 9/30/17
Jennison Associates LLC 1,590,202 4.63 -3,505 9/30/17
Fidelity Institutional Asset Management 1,480,266 4.31 -23,334 9/30/17
Redmile Group, LLC 1,214,088 3.54 614,468 9/30/17
T. Rowe Price Associates, Inc. 1,098,910 3.20 -263,900 9/30/17
The Vanguard Group, Inc. 923,244 2.69 79,054 9/30/17
Millennium Management LLC 685,005 1.99 -691,882 9/30/17
Baker Bros. Advisors LP 563,312 1.64 -- 9/30/17
BlackRock Institutional Trust Company, N.A. 516,789 1.51 38,140 9/30/17
Schonfeld Strategic Advisors LLC 500,104 1.46 -40,930 9/30/17
Janus Henderson Investors 487,500 1.42 -14,132 9/30/17
EAM Investors, LLC 371,030 1.08 32,285 9/30/17
Alyeska Investment Group, L.P. 358,962 1.05 8,962 9/30/17
OrbiMed Advisors, LLC 337,588 0.98 -- 9/30/17
Nexthera Capital LP 321,286 0.94 321,286 9/30/17
King (Rachel K) 317,802 0.93 -- 3/10/17
Renaissance Technologies LLC 246,200 0.72 235,500 9/30/17
Deutsche Asset Management Americas 204,176 0.59 199,148 9/30/17
The Invus Group, LLC 202,500 0.59 -- 9/30/17
Columbus Circle Investors 201,980 0.59 66,177 9/30/17
Geode Capital Management, L.L.C. 156,952 0.46 11,150 9/30/17
Thackray (Helen M) 150,615 0.44 -2,000 9/18/17
Wall Street Associates, LLC 150,000 0.44 -- 12/31/16
Hudson Bay Capital Management LP 125,000 0.36 44,850 9/30/17
Susquehanna Financial Group, LLLP 116,629 0.34 23,478 9/30/17
Magnani (John L) 104,147 0.30 8,928 5/10/17
Medical Strategy GmbH 102,869 0.30 -- 7/31/17
Columbia Threadneedle Investments (US) 97,460 0.28 1,117 9/30/17
Parametric Portfolio Associates LLC 77,056 0.22 -173 9/30/17
Redwood Investments, LLC 70,060 0.20 -- 9/30/17
AllianceBernstein L.P. 66,933 0.19 26,090 8/31/17
Bridgeway Capital Management, Inc. 66,764 0.19 -- 9/30/17
Citadel LLC 58,422 0.17 36,111 9/30/17
Oppenheim Asset Management Services S.à r.l. 55,613 0.16 -- 9/30/17
Northern Trust Investments, Inc. 47,830 0.14 4,517 9/30/17
Victory Capital Management Inc. 46,786 0.14 -- 9/30/17
AQR Capital Management, LLC 38,035 0.11 -- 10/31/17
Squarepoint Capital LLP 37,477 0.11 37,477 9/30/17
BlackRock Advisors (UK) Limited 31,669 0.09 24,500 9/30/17
Element Capital Management, LLC 29,909 0.09 -53,550 9/30/17
Virtus Etf Advisers LLC 28,961 0.08 2,649 9/30/17
LifeSci Index Partners, LLC 28,961 0.08 2,649 9/30/17
State Street Global Advisors (US) 25,600 0.07 730 9/30/17
TD Asset Management Inc. 25,300 0.07 -7,100 9/30/17
BNY Mellon Asset Management 23,709 0.07 858 9/30/17
JP Morgan Asset Management 23,622 0.07 -- 10/31/17
K2 Advisors L.L.C. 22,176 0.06 -3,505 9/30/17

* Insider values reflect direct beneficial ownership.

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