OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 142 767.18 110.11 47,409,998
Mutual Fund 171 328.08 47.37 20,394,403
Insider 4 7.06 0.92 397,793

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 101 259.34 37.21 16,023,031
Sellers 63 -71.54 10.25 -4,413,212
Net -- 187.80 26.96 11,609,819

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 767.18 110.11 47,409,998
Top 10 Inst. 534.08 76.63 32,994,304
Top 20 Inst. 675.27 96.89 41,717,720
Top 50 Inst. 742.26 106.52 45,863,701

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 32 58.47 8.45 3,639,611
Aggressive Growth 2 0.34 0.05 21,170
Core Growth 22 30.92 4.45 1,917,411
Growth 8 27.21 3.95 1,701,030
Income 4 36.76 5.26 2,266,289
Income Value 2 35.69 5.11 2,199,587
Yield 2 1.07 0.15 66,702
Index 19 105.81 15.18 6,536,425
Other 54 437.23 62.78 27,030,178
Broker Dealer 12 6.52 0.93 402,144
GARP 16 154.11 22.11 9,519,560
Hedge Fund 22 76.14 10.92 4,701,040
Sector Specific 2 53.74 7.69 3,311,393
Specialty 1 0.11 0.02 7,000
VC/Private Equi 1 146.61 21.11 9,089,041
Value 11 106.41 15.23 6,557,305
Core Value 10 104.59 14.97 6,444,607
Deep Value 1 1.82 0.26 112,698

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 9,089,041 21.11 504,913 6/30/18
Wellington Management Company, LLP 5,787,454 13.44 2,209,032 3/31/18
T. Rowe Price Associates, Inc. 2,870,775 6.67 1,605,815 3/31/18
BlackRock Institutional Trust Company, N.A. 2,613,100 6.07 1,656,106 6/30/18
OppenheimerFunds, Inc. 2,504,925 5.82 2,504,925 3/31/18
Fidelity Management & Research Company 2,477,963 5.76 4,013 6/30/18
Redmile Group, LLC 2,282,268 5.30 351,600 3/31/18
Franklin Advisers, Inc. 2,108,179 4.90 178,800 3/31/18
State Street Global Advisors (US) 1,692,978 3.93 1,659,270 3/31/18
Jennison Associates LLC 1,567,621 3.64 -20,225 3/31/18
The Vanguard Group, Inc. 1,517,700 3.52 484,864 3/31/18
Citadel LLC 1,453,077 3.37 290,524 6/30/18
Fidelity Institutional Asset Management 1,282,633 2.98 286,000 6/30/18
Janus Henderson Investors 1,184,530 2.75 -22,438 6/30/18
Polar Capital LLP 1,029,125 2.39 349,789 3/31/18
Baker Bros. Advisors LP 563,312 1.31 -- 3/31/18
AXA Investment Managers UK Ltd. 508,632 1.18 -2,342 3/31/18
Alyeska Investment Group, L.P. 487,029 1.13 324,227 3/31/18
APG Asset Management 379,576 0.88 379,576 3/31/18
King (Rachel K) 317,802 0.74 -- 3/23/18
RA Capital Management, LLC 253,547 0.59 253,547 3/31/18
Farallon Capital Management, L.L.C. 250,000 0.58 250,000 3/31/18
Invus Public Equities Advisors, LLC 250,000 0.58 -75,000 6/30/18
Ghost Tree Capital, LLC 250,000 0.58 250,000 3/31/18
Schonfeld Strategic Advisors LLC 239,575 0.56 -210,425 3/31/18
Millennium Management LLC 236,634 0.55 223,461 3/31/18
Geode Capital Management, L.L.C. 201,433 0.47 44,481 3/31/18
Arctic Fund Management AS 189,978 0.44 -127,456 6/30/18
Goldman Sachs & Company, Inc. 169,499 0.39 56,333 3/31/18
Sphera Funds Management Ltd. 150,000 0.35 -175,000 3/31/18
Thackray (Helen M) 148,615 0.35 -- 3/23/18
Point72 Asset Management, L.P. 127,035 0.30 127,035 3/31/18
UBS Financial Services, Inc. 125,355 0.29 125,055 3/31/18
Moore Capital Management, LP 122,500 0.28 122,500 3/31/18
Invesco PowerShares Capital Management LLC 117,846 0.27 -61,686 3/31/18
BlackRock Investment Management, LLC 112,698 0.26 108,247 6/30/18
BlueCrest Capital Management LLP 108,932 0.25 108,932 3/31/18
Magnani (John L) 105,638 0.25 1,491 5/23/18
Balyasny Asset Management LP 101,986 0.24 101,986 3/31/18
Hudson Bay Capital Management LP 100,000 0.23 -40,000 3/31/18
BNY Mellon Asset Management 91,408 0.21 60,490 6/30/18
Credit Suisse Securities (USA) LLC 82,551 0.19 70,626 3/31/18
Asset Management One Co., Ltd. 80,097 0.19 80,097 7/31/17
Northern Trust Investments, Inc. 77,906 0.18 13,018 3/31/18
GAM Capital Management (Switzerland) AG 77,900 0.18 -- 6/30/18
GAM Investment Management (Switzerland) AG 75,895 0.18 46,589 6/30/18
Peregrine Capital Management, LLC 75,749 0.18 75,749 3/31/18
Macquarie Investment Management 75,749 0.18 75,749 3/31/18
Charles Schwab Investment Management, Inc. 74,022 0.17 74,022 6/30/18
Allianz Global Investors GmbH 73,433 0.17 73,433 3/31/18

* Insider values reflect direct beneficial ownership.

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