OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 120 550.75 77.70 33,015,036
Mutual Fund 95 210.27 25.85 10,983,124
Insider 4 5.78 0.93 396,302

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 70 117.14 16.41 6,972,129
Sellers 42 -79.23 11.09 -4,712,626
Net -- 37.91 5.32 2,259,503

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 550.75 77.70 33,015,036
Top 10 Inst. 398.44 55.85 23,730,901
Top 20 Inst. 486.86 68.24 28,997,230
Top 50 Inst. 542.09 76.40 32,463,156

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 33 65.41 9.13 3,879,048
Aggressive Growth 5 3.04 0.34 143,015
Core Growth 19 30.15 4.21 1,789,917
Growth 9 32.22 4.58 1,946,116
Income 4 33.52 4.70 1,996,534
Income Value 2 32.78 4.60 1,952,604
Yield 2 0.73 0.10 43,930
Index 8 42.63 5.97 2,538,779
Other 41 318.27 44.54 18,925,760
Broker Dealer 12 6.58 0.92 391,986
GARP 9 71.65 9.97 4,236,867
Hedge Fund 16 51.97 7.29 3,095,775
Sector Specific 2 43.82 6.14 2,610,004
Specialty 1 0.12 0.02 7,000
VC/Private Equi 1 144.13 20.20 8,584,128
Value 8 69.63 9.78 4,155,471
Core Value 5 69.55 9.77 4,149,814
Deep Value 3 0.08 0.01 5,657

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 8,584,128 20.20 -- 12/31/17
Wellington Management Company, LLP 3,578,422 8.42 83,552 12/31/17
Redmile Group, LLC 1,930,668 4.54 716,580 12/31/17
Franklin Advisers, Inc. 1,929,379 4.54 70,300 12/31/17
Fidelity Management & Research Company 1,614,217 3.80 1,614,217 12/31/17
Jennison Associates LLC 1,587,846 3.74 -2,356 12/31/17
T. Rowe Price Associates, Inc. 1,264,960 2.98 166,050 12/31/17
Fidelity Institutional Asset Management 1,224,466 2.88 -255,800 12/31/17
The Vanguard Group, Inc. 1,032,836 2.43 109,592 12/31/17
BlackRock Institutional Trust Company, N.A. 983,979 2.32 467,190 12/31/17
Janus Henderson Investors 977,759 2.30 490,259 12/31/17
Polar Capital LLP 679,336 1.60 679,336 12/31/17
Baker Bros. Advisors LP 563,312 1.33 -- 12/31/17
AXA Investment Managers UK Ltd. 510,974 1.20 510,974 12/31/17
BVF Partners L.P. 497,474 1.17 -2,732,382 12/31/17
Nexthera Capital LP 480,442 1.13 159,156 12/31/17
Schonfeld Strategic Advisors LLC 450,000 1.06 -50,104 12/31/17
Citadel LLC 413,119 0.97 354,697 12/31/17
EAM Investors, LLC 368,913 0.87 -2,117 12/31/17
Sphera Funds Management Ltd. 325,000 0.76 325,000 12/31/17
King (Rachel K) 317,802 0.75 -- 3/10/17
Invus Public Equities Advisors, LLC 250,000 0.59 47,500 12/31/17
Columbus Circle Investors 243,164 0.57 41,184 12/31/17
Invesco PowerShares Capital Management LLC 179,532 0.42 179,532 12/31/17
Susquehanna Financial Group, LLLP 177,952 0.42 61,323 12/31/17
Renaissance Technologies LLC 174,500 0.41 -71,700 12/31/17
Alyeska Investment Group, L.P. 162,802 0.38 -196,160 12/31/17
Geode Capital Management, L.L.C. 156,952 0.37 -- 12/31/17
D. E. Shaw & Co., L.P. 152,480 0.36 152,480 12/31/17
Thackray (Helen M) 148,615 0.35 -2,000 12/8/17
Hudson Bay Capital Management LP 140,000 0.33 15,000 12/31/17
Deutsche Asset Management Americas 134,851 0.32 -69,325 12/31/17
Goldman Sachs & Company, Inc. 113,166 0.27 113,166 12/31/17
Magnani (John L) 104,147 0.25 8,928 5/10/17
Columbia Threadneedle Investments (US) 97,736 0.23 276 12/31/17
GSA Capital Partners LLP 86,700 0.20 86,700 12/31/17
Victory Capital Management Inc. 85,626 0.20 18,640 2/28/18
Asset Management One Co., Ltd. 80,097 0.19 80,097 7/31/17
Medical Strategy GmbH 78,069 0.18 -2,300 2/28/18
Parametric Portfolio Associates LLC 68,386 0.16 -8,670 12/31/17
K2 Advisors L.L.C. 67,652 0.16 15,453 12/31/17
Northern Trust Investments, Inc. 64,888 0.15 17,058 12/31/17
Barclays Bank PLC 59,859 0.14 28,190 12/31/17
Hauck & Aufhäuser Asset Management Services S.à r.l. 55,613 0.13 -- 9/30/17
Jefferies LLC 53,869 0.13 53,869 12/31/17
Redwood Investments, LLC 51,898 0.12 -12,572 2/28/18
Driehaus Capital Management, LLC 51,048 0.12 51,048 2/28/18
Alps Advisors, Inc. 38,050 0.09 38,050 12/31/17
Bridgeway Capital Management, Inc. 36,764 0.09 -30,000 12/31/17
State Street Global Advisors (US) 33,708 0.08 8,108 12/31/17

* Insider values reflect direct beneficial ownership.

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