OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 118 549.95 96.65 33,186,476
Mutual Fund 90 162.20 28.71 9,859,605
Insider 3 2.63 0.75 255,917

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 69 115.81 20.16 6,923,999
Sellers 48 -91.22 16.31 -5,600,809
Net -- 24.58 3.85 1,323,190

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 549.95 96.65 33,186,476
Top 10 Inst. 398.44 69.11 23,730,901
Top 20 Inst. 486.86 84.45 28,997,230
Top 50 Inst. 541.08 94.93 32,597,248

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 30 63.48 11.16 3,831,836
Aggressive Growth 4 1.76 0.31 104,922
Core Growth 18 29.66 5.22 1,790,798
Growth 8 32.05 5.64 1,936,116
Income 4 33.51 5.81 1,996,007
Income Value 2 32.78 5.69 1,952,604
Yield 2 0.73 0.13 43,403
Index 9 43.63 7.57 2,598,638
Momentum 1 0.92 0.44 150,000
Other 41 318.27 55.20 18,955,729
Broker Dealer 12 6.58 1.14 391,986
GARP 9 71.55 12.41 4,261,667
Hedge Fund 16 52.06 9.03 3,100,944
Sector Specific 2 43.82 7.60 2,610,004
Specialty 1 0.12 0.02 7,000
VC/Private Equi 1 144.13 25.00 8,584,128
Value 9 69.69 12.12 4,161,330
Core Value 6 69.61 12.10 4,155,673
Deep Value 3 0.08 0.02 5,657

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 8,584,128 25.00 -- 12/31/17
Wellington Management Company, LLP 3,578,422 10.42 83,552 12/31/17
Redmile Group, LLC 1,930,668 5.62 716,580 12/31/17
Franklin Advisers, Inc. 1,929,379 5.62 70,300 12/31/17
Fidelity Management & Research Company 1,614,217 4.70 1,614,217 12/31/17
Jennison Associates LLC 1,587,846 4.62 -2,356 12/31/17
T. Rowe Price Associates, Inc. 1,264,960 3.68 166,050 12/31/17
Fidelity Institutional Asset Management 1,224,466 3.57 -255,800 12/31/17
The Vanguard Group, Inc. 1,032,836 3.01 109,592 12/31/17
BlackRock Institutional Trust Company, N.A. 983,979 2.87 467,190 12/31/17
Janus Henderson Investors 977,759 2.85 490,259 12/31/17
Polar Capital LLP 679,336 1.98 679,336 12/31/17
Baker Bros. Advisors LP 563,312 1.64 -- 12/31/17
AXA Investment Managers UK Ltd. 510,974 1.49 510,974 12/31/17
BVF Partners L.P. 497,474 1.45 -2,732,382 12/31/17
Nexthera Capital LP 480,442 1.40 159,156 12/31/17
Schonfeld Strategic Advisors LLC 450,000 1.31 -50,104 12/31/17
Citadel LLC 413,119 1.20 354,697 12/31/17
EAM Investors, LLC 368,913 1.07 -2,117 12/31/17
Sphera Funds Management Ltd. 325,000 0.95 325,000 12/31/17
King (Rachel K) 317,802 0.93 -- 3/10/17
Invus Public Equities Advisors, LLC 250,000 0.73 47,500 12/31/17
Columbus Circle Investors 243,164 0.71 41,184 12/31/17
Invesco PowerShares Capital Management LLC 179,532 0.52 179,532 12/31/17
Susquehanna Financial Group, LLLP 177,952 0.52 61,323 12/31/17
Renaissance Technologies LLC 174,500 0.51 -71,700 12/31/17
Alyeska Investment Group, L.P. 162,802 0.47 -196,160 12/31/17
Geode Capital Management, L.L.C. 156,952 0.46 -- 12/31/17
D. E. Shaw & Co., L.P. 152,480 0.44 152,480 12/31/17
Wall Street Associates, LLC 150,000 0.44 -- 12/31/16
Thackray (Helen M) 148,615 0.43 -2,000 12/8/17
Hudson Bay Capital Management LP 140,000 0.41 15,000 12/31/17
Deutsche Asset Management Americas 134,851 0.39 -69,325 12/31/17
Goldman Sachs & Company, Inc. 113,166 0.33 113,166 12/31/17
Magnani (John L) 104,147 0.30 8,928 5/10/17
Medical Strategy GmbH 102,869 0.30 -- 12/31/17
Columbia Threadneedle Investments (US) 97,736 0.28 276 12/31/17
GSA Capital Partners LLP 86,700 0.25 86,700 12/31/17
Asset Management One Co., Ltd. 80,097 0.23 80,097 7/31/17
Parametric Portfolio Associates LLC 68,386 0.20 -8,670 12/31/17
Victory Capital Management Inc. 66,986 0.20 20,200 12/31/17
Northern Trust Investments, Inc. 64,888 0.19 17,058 12/31/17
Redwood Investments, LLC 64,470 0.19 -5,590 12/31/17
AllianceBernstein L.P. 62,485 0.18 -4,448 12/31/17
BlackRock Advisors (UK) Limited 59,859 0.17 28,190 12/31/17
Hauck & Aufhäuser Asset Management Services S.à r.l. 55,613 0.16 -- 9/30/17
K2 Advisors L.L.C. 55,283 0.16 3,084 12/31/17
Jefferies LLC 53,869 0.16 53,869 12/31/17
Alps Advisors, Inc. 38,050 0.11 38,050 12/31/17
Bridgeway Capital Management, Inc. 36,764 0.11 -30,000 12/31/17

* Insider values reflect direct beneficial ownership.

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